Ozan Tapanyigit

Synthesis and investigation of anti-inflammatory and anticonvulsant activities of novel coumarin-diacylated hydrazide derivativesSynthesis and investigation of anti-inflammatory and anticonvulsant activities of novel coumarin-diacylated hydrazide derivatives

King Saud University Arabian Journal of Chemistry · 15 Eyl 2020

doi.org/10.1016/j.arabjc.2020.10.034

· A number of novel coumarin derivatives synthesized by the reaction of 3-carbonyl chloride coumarin with some substituted aryl acid hydrazides to investigate their anti-inflammatory and anticonvulsant activities. Carrageenan (0.1 ml of 1%, w/v) was injected subplantarly in the right paw of rats to induce an acute model of inflammation. On the other hand, pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was used to investigate the anticonvulsant activities of six newly synthesized coumarin derivatives in mice. Hybrid compound 8d was found the most promising anticonvulsant agent among all treatment groups according to the onset of seizure and survival rate. Moreover, 8b and 8c has potential anticonvulsant efficiency.

Synthesis and identification of coumarin-carboxylic acid hydrazide hybrid compounds

· In this thesis, six novel hydrazide-coumarin hybrids have not been synthesized in the literature. At first methyl esters which are phenolic acid derivatives, were synthesized and hydrazide compounds were prepared by reaction of these acid esters with hydrazine hydrate. To form hybrids of these acid hydrazides with coumarin, 3-carboxy chlorine coumarin compound was synthesized. The (E)-N'-(3-(4-hydroxyphenyl)acryloyl)-2-oxo-2H-chromene-3-carbohydrazide 25 was synthesized in 70% yield and the other five hydrazide-coumarin hybrids were synthesized in 90-95% yield. The structures of the synthesized ester, hydrazide, coumarin and hybrid compounds were illuminated using FT-IR, 1H-NMR and 13C-NMR spectroscopy.